Effects of Mn concentration on the ac magnetically induced heating characteristics of superparamagnetic MnxZn1-xFe2O4 nanoparticles for hyperthermia

摘要

The effects of Mn^2+ cation concentration on the ac magnetically induced heating characteristics and the magnetic properties of superparamagnetic Mn_xZn_1-x,Fe_2O_4 nanoparticles (SPNPs) were investigated to explore the biotechnical feasibility as a hyperthermia agent. Among the Mn_xZn_1-xFe_2O_4 SPNPs, the Mn_0.5Zn_0.5Fe_2O_4 SPNP showed the highest ac magnetically induced heating temperature (ΔT_ac,mag), the highest specific absorption rate (SAR), and the highest biocompatibility. The higher out of phase susceptibility (x"m) value and the higher chemical stability systematically controlled by the replacement of Zn^2+ cations by the A-site (tetrahedral site) are the primary physical reason for the promising biotechnical properties of Mn_0.5Zn_0.5Fe_2O_4 SPNP.